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Botswana-Harvard Partnership for HIV Research
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Molecular Charactarization of
HIV-1C
Prevention of Mother to Infant Transmission of HIV-1C in Botswana Cytotoxic T Lymphocytes (CTL) and Human Leukocyte Antigens (HLA) Adult Anti-retroviral Treatment and Resistance Study
(Tshepo) |
Prevention of Mother to Infant Transmission of HIV-1C in Botswana (Mashi) (NIH HD 37793) Currently, there are two clinical trials that aim to determine the effectiveness of anti-retroviral treatment therapy, and the effects of infant feeding strategies, on the transmission of HIV-1C from mother to infant. The National Program, established by the Government of Botswana, provides all HIV-infected, pregnant women with ZDV (zidovudine) in order to examine whether administering ZDV has a protective effect on the transmission of HIV through breast milk from mothers to their infants. The “Mashi” (milk in Setswana) study, coordinated by the Botswana-Harvard Partnership, offers the standard of care established by the National Program. In addition it also seeks to determine if single dose administration of the drug nevirapine (NVP) to both mother and child during the perinatal period also aids in reducing the transmission of HIV from mother to child. The outcomes of this study will have important ramifications for transmission prevention strategies for women and infants in southern Africa. The Partnership’s study has three study sites: Molepolole, Lobatse and Mochudi. Infant Health Outcomes in the Mashi Cohort (NIH HD 01330 and HD 40451) In addition to the aims outlined above, the Mashi study also seeks to compare the infant health outcomes of breast-fed infants vs. formula-fed infants. The Botswana-Harvard Partnership’s infant health outcomes adjunct studies will quantify health outcomes among three groups of infants: 1) infants born to HIV-infected women randomized to breast-feed, 2) infants born to HIV-infected women randomized to formula feed, and 3) infants born to HIV-uninfected mothers and who breast feed. The primary objectives of the Mashi adjunct studies are to determine the rates of diarrheal and respiratory illnesses and bloodstream infections, the rate of infant mortality, and the range of pathogens present among each of these groups. These data will help determine the overall morbidity and mortality among infants randomized to formula feed vs. those randomized to breast-feed. Secondary objectives include the correlation between breast milk immunoglobulins and infant health outcomes, and the association between oropharyngeal colonization with bacterial pathogens and infant feeding strategy. |
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For more information contact:
Ria Madison | |