Dr. Makhema is a Practicing Internal Medicine Physician and is the CEO of the Botswana Harvard AIDS Institute Partnership (BHP), He Provides strategic leadership, manages and supervises all initiatives of the BHP. He oversees grant funded research and training awards from a number of different funders. He is the Co- PI of the BHP/HSPH Clinical Trials Unit, providing oversight and clinical mentorship for all CTU trials. He is Site PI for HPTN and the COVID-19 Prevention Trials Network and other COVID-19 related research projects. He advises on the selection of the BHP clinical research portfolio. He has published and been involved in over 100 publications. He is interested in community HIV prevention initiatives, translational policy issues, and health systems strengthening.