A Clinical Trial to Evaluate the Impact of Broadly Neutralizing Antibodies VRC01LS and 10-1074 on Maintenance of HIV Suppression in a Cohort of Early-Treated Children in Botswana (Dual bNAb Treatment in Children)/ Tatelo Study
Principal Investigator Initiated

Study Objectives:

A cross-sectional evaluation of antibody responses to SARS-COV-2 vaccines
Principal Investigator Initiated

Principal Investigator - Professor Mosepele Mosepele MD, MSc

Study Objectives

Primary Objectives:

  1. To evaluate SARS-CoV-2-specific qualitative antibody responses after the administration of full vaccination doses (either single or second doses) of vaccines in Botswana.
  2. To evaluate SARS-CoV-2-specific quantitative antibody responses after the administration of full doses of vaccines in Botswana.

Secondary Objectives:

Albuminuria Among Virally Suppressed HIV-infected Patients in Botswana: Longitudinal Changes and Association with Inflammation and ACEI/ARB Use in a Clinical Setting - Albuminuria Study
Principal Investigator Initiated

Principal Investigator - Professor Mosepele Mosepele, MD, MSc

Study Status: The study opened on January 22, 2020 and accrual completed on January 27, 2021. Participant follow up ongoing.

Study Objectives:

Assessment of Proviral Reservoir: Synergistic combination of reporter cell assay and viral diversity
Principal Investigator Initiated

Principal Investigators - Dr. Sikhulile Moyo, MSc, MPH, PhD | Dr. Catherine K. Koofhethile, PhD

Study Objectives:  This study has two main goals:

Birth Outcomes Surveillance Study: Tsepamo Study
Principal Investigator Initiated

Principal Investigator - Professor Roger L. Shapiro, MD, MPH

Study Objectives

Primary Objectives

Characterization of Anthracycline induced Cardiotoxicity Using Cardiac Magnetic Resonance in Botswana: A Prospective Observational study (Pelo Study)
Principal Investigator Initiated

Principal Investigator - Dr. Scott Dryden-Peterson MD, MSc

Study Objectives

Aim 1: The study will compare the LVEF between patients with and without HIV  who are being treated with anthracyclines. We hypothesize that the LVEF will be  lower after anthracycline among individuals living with HIV.

Contraceptives and Dolutegravir-based ART (CODA) Study
Principal Investigator Initiated

Principal Investigator - Dr. Chelsea Morroni, MD, MPH, PhD

Name of the Study: The Contraceptives and Dolutegravir-based ART (CODA) Study

Study Status: Recruiting 

Study Objectives:

Early Infant Treatment Study: A Clinical Trial of HIV Positive Infants in Botswana
Principal Investigator Initiated

Principal Investigator - Professor Roger L. Shapiro, MD, MPH

Study Objectives

The overall objective of the EIT study is to determine whether very early antiretroviral treatment (ART) initiation in HIV-infected infants limits the seeding of viral reservoirs and maintains immune responses, potentially allowing future periods off ART.

Specific Aims: 

Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in Botswana
Principal Investigator Initiated

Principal Investigator - Nabila Youssouf PhD | Laura Bogart | Mosepele Mosepele MD, MSc

Name of the Study: Exploring the Acceptability and Feasibility of COVID19 Testing among Truck Drivers in Botswana

Study Status: Completed recruitment – data analysis ongoing

Study Objectives: To explore the acceptability and feasibility on COVID 19 testing among truck drivers entering Botswana and to acquire feedback about potential interventions to further respond to this evolving crisis. 

Feasibility and Accuracy of Nanosenor-based cancer diagnosis at the point of care (Chedza Study).
Principal Investigator Initiated

Principal Investigator - Dr. Scott Dryden-Peterson, MD, MSc

FLOURISH: Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescents who are HIV Exposed Uninfected
Principal Investigator Initiated

Principal Investigators - Dr. Kathleen M. Powis, MD, MPH, MBA | Dr. Jennifer Jao, MD, MPH | Dr. Joseph Makhema, MB.ChB, FRCP

Study Objectives 

Primary Study Aims

HIV and Malignancy in Botswana: An observational Study of Medicine Toxicity of Concurrent Treatment and Clinical Outcomes (Thabatse Study)
Principal Investigator Initiated

Principal Investigator - Dr. Scott Dryden-Peterson MD, MSc

Thabatse is a prospective cohort study which aims to evaluate the risk factors for cancer and describe the response to treatment for patients who are HIV positive and not on Antiretroviral Therapy (ART) and those on ART.

Study Objectives

The primary aims are to evaluate the important risk factors for cancer in Botswana (including HIV) and describe the response to treatment for patients without HIV, with HIV but not yet on HAART, and those with HIV and on HAART.

Human Papillomavirus (HPV) Cervical Cancer Screening Study
Principal Investigator Initiated

Principal Investigator - Dr. Rebecca Luckett, MD, MPH

Name of the Study: Evaluation of cervical cancer screening algorithms using primary high risk human papillomavirus (HPV) in Gaborone and South East District, Botswana

Completed: Recruitment of 300 women living with HIV in Gaborone, and one year follow-up of this cohort. 

On-going: Recruitment of a new cohort of 3000 women in South East District is currently underway. 50% of the cohort will be women living with HIV. 

Innovative HIV Testing Strategy for Middle-to-Upper Income Men in a Resource-Limited Setting
Principal Investigator Initiated

Principal Investigator - Professor Mosepele Mosepele MD, MSc, | Laura Bogart PhD

Study Objectives:

Integrating Hypertension and Cardiovascular Diseases Care into Existing HIV Services Package in Botswana (InterCARE Study)
Principal Investigator Initiated

Principal Investigators - Professor Mosepele Mosepele MD, MSc | Tendani Gaolathe BS, MD | Kathleen Wirth Hurwitz

International Sexual Health and Reproductive (ISHARE) Health Survey During COVID-19
Principal Investigator Initiated

Principal Investigator - Dr. Chelsea Morroni, MD, MPH, PhD

Karabo Study: Immune Correlates of Tuberculosis and non-Tuberculosis Infectious Morbidity in Southern African HIV- Exposed, Uninfected Infants
Principal Investigator Initiated

Principal Investigator - Dr. Kathleen Powis, MD, MPH

Study Objectives

Specific Aim 1: Define TB-related and TB-independent risk factors if morbidity and mortality in the first year of life among BCG vaccinated HE and HUU infants enrolled in the Karabo Study and a second ongoing study in Cape Town, South Africa, the InFANT Study (Innate Factors Associated with Nursing Transmission; funded by Canadian Institutes of Health Reseach), using multivariable logistic regression analysis.

Mitigating the impact of COVID-19 effects in adolescent reproductive health through self-testing: a mixed methods pilot study: “ICHEKE”
Principal Investigator Initiated

Principal Investigator - Lucy Mupfumi, PhD

Study Objectives

Mopati: A Pilot HIV Treatment Partner Intervention in Botswana
Principal Investigator Initiated

Principal Investigators - Professor Mosepele Mosepele, MD, MSc | Laura Bogart, PhD

Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir or Efavirenz and HIV-Unexposed Children (Motheo Study)
Principal Investigator Initiated

Principal Investigator - Dr. Shahin Lockman MD, MPH | Dr. Adam Cassidy